Stock B6.129S-Tecta<tm1Gpr>/H

FESA Number

4844

Strain Name

B6.129S-Tecta<tm1Gpr>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation - Knock out IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tecta<tm1Gpr> MGI:2183148 Tecta MGI:109575 9

Severity Limit

Mild

Phenotypic Description

Homozygous mutant mice suffer hearing loss and have detatched tectorial membranes lacking all non-collagenous matrix.

Publications

Displaying 1 - 5 of 5 Stock Publications
Pubmed ID Authors Title Journal
11087000 Legan PK A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. Neuron (2 000) 28:273-85
14523068 Lukashkin AN Role of the tectorial membrane revealed by otoacoustic emissions recorded from wild-type and transgenic Tecta(deltaENT/deltaENT) mice. J Neurophysiol (2 004) 91:163-71
18516034 Mellado Lagarde MM Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier. Nat Neurosci (2 008) 11:746-8
21165971 Verpy E Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane. J Comp Neurol (2 011) 519:194-210
18849963 Verpy E Stereocilin-deficient mice reveal the origin of cochlear waveform distortions. Nature (2 008) 456:255-8

Human Disease Links

OMIM IDs 603629

EMMA ID

EM:05538

Genetic Status

GMO

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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