Stock B6.129S-Tecta<tm2Gpr>/H
FESA Number
4848
Strain Name
B6.129S-Tecta<tm2Gpr>/H
Mutation Strain Type
Mutation Type | Mutation Subtype | Strain Type |
---|---|---|
IMSR - Targeted mutation - Knock in | IMSR - mutant strain |
Attribution
Institution name | Depositor / Originator | Name |
---|---|---|
Unknown Institution | Originator | Retained |
Gene/Allele Information
Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
---|---|---|---|---|
Tecta<tm2Gpr> | MGI:3605485 | Tecta | MGI:109575 | 9 |
Severity Limit
Mild
Phenotypic Description
Heterozygous mice suffer hearing loss and have tectorial membranes with a thin limbal attachment zone, missing marginal band and Hensen's stripe and large holes in the main body of the matrix. The subtectorial space above the inner hair cells is also enlarged. Heterozygous mice show elevated neural thresholds, broadened neural tuning and a decrease in sensitivity at the tip of the neural tuning curve.
Publications
Displaying 1 - 2 of 2 Stock Publications
Human Disease Links
OMIM IDs 602574
EMMA ID
EM:05543
Genetic Status
GMO
Background Strain Name
C57BL/6J
Background Strain MGI ID
MGI:3028467
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