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Stock B6.129S-Tecta<tm2Gpr>/H

FESA Number

4848

Strain Name

B6.129S-Tecta<tm2Gpr>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation - Knock in IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tecta<tm2Gpr> MGI:3605485 Tecta MGI:109575 9

Severity Limit

Mild

Phenotypic Description

Heterozygous mice suffer hearing loss and have tectorial membranes with a thin limbal attachment zone, missing marginal band and Hensen's stripe and large holes in the main body of the matrix. The subtectorial space above the inner hair cells is also enlarged. Heterozygous mice show elevated neural thresholds, broadened neural tuning and a decrease in sensitivity at the tip of the neural tuning curve.

Publications

Displaying 1 - 2 of 2 Stock Publications
Pubmed ID Authors Title Journal
15995703 Legan PK A deafness mutation isolates a second role for the tectorial membrane in hearing. Nat Neurosci (2 005) 8:1035-42
21081075 Masaki K Tectorial membrane material properties in Tecta(Y)(1870C/+) heterozygous mice. Biophys J (2 010) 99:3274-81

Human Disease Links

OMIM IDs 602574

EMMA ID

EM:05543

Genetic Status

GMO

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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