Stock B6.129S-Otoa<tm1Gpr>/H
FESA Number
4850
Strain Name
B6.129S-Otoa<tm1Gpr>/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation | IMSR - mutant strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| Unknown Institution | Originator | Retained |
| Unknown Institution | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Otoa<tm1Gpr> | MGI:5469411 | Otoa | MGI:2149209 | 7 |
Severity Limit
Mild
Phenotypic Description
In null mutant (OtoaEGFP/EGFP) mice the TM is detached at the spiral limbus but remains attached to the outer hair cells, Hensen's stripe is missing and the marginal band appears abnormal. Null mutants show hearing loss but excitation of the outer hair cells and cochlear
amplification are almost normal.
Publications
Displaying 1 - 1 of 1 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 23129639 | Lukashkin AN | A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation. | Proc Natl Acad Sci U S A (2 012) 109:19351-6 |
EMMA ID
EM:05545
Genetic Status
GMO
Background Strain Name
C57BL/6J
Background Strain MGI ID
MGI:3028467
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