Mutation Strain Type
|Mutation Type||Mutation Subtype||Strain Type|
|IMSR - Targeted mutation||IMSR - mutant strain|
|Institution name||Depositor / Originator||Name|
|Allele Name||Allele MGI ID||Gene Name||Gene MGI ID||Chromosome|
In null mutant (OtoaEGFP/EGFP) mice the TM is detached at the spiral limbus but remains attached to the outer hair cells, Hensen's stripe is missing and the marginal band appears abnormal. Null mutants show hearing loss but excitation of the outer hair cells and cochlear amplification are almost normal.
Displaying 1 - 1 of 1 Stock Publications
|23129639||Lukashkin AN||A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation.||Proc Natl Acad Sci U S A (2 012) 109:19351-6|