Stock B6.129S-Otoa<tm1Gpr>/H

FESA Number

4850

Strain Name

B6.129S-Otoa<tm1Gpr>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
Unknown Institution Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Otoa<tm1Gpr> MGI:5469411 Otoa MGI:2149209 7

Severity Limit

Mild

Phenotypic Description

In null mutant (OtoaEGFP/EGFP) mice the TM is detached at the spiral limbus but remains attached to the outer hair cells, Hensen's stripe is missing and the marginal band appears abnormal. Null mutants show hearing loss but excitation of the outer hair cells and cochlear amplification are almost normal.

Publications

Displaying 1 - 1 of 1 Stock Publications
Pubmed ID Authors Title Journal
23129639 Lukashkin AN A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation. Proc Natl Acad Sci U S A (2 012) 109:19351-6

EMMA ID

EM:05545

Genetic Status

GMO

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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