Stock

FESA Number

1631

Strain Name

B6.129P2(Cg)-Tlx1<tm1Thr>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - unclassified

Attribution

Institution name Depositor / Originator Name
University of Leeds Originator Retained
University of Leeds Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tlx1<tm1Thr> MGI:3581680 Tlx1 MGI:98769 19

Phenotypic Description

Asplenia.

Publications

Displaying 1 - 8 of 8 Stock Publications
Pubmed ID Authors Title Journal
15944191 Brendolan A A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development (2 005) 132:3113-26
7555717 Dear TN The Hox11 gene is essential for cell survival during spleen development. Development (1 995) 121:2909-15
11356032 Kanzler B Hox11 acts cell autonomously in spleen development and its absence results in altered cell fate of mesenchymal spleen precursors. Dev Biol (2 001) 234:231-43
10822272 Koehler K Hox11 is required to maintain normal Wt1 mRNA levels in the developing spleen. Dev Dyn (2 000) 218:201-6
16515781 Moens CB Hox cofactors in vertebrate development. Dev Biol (2 006) 291:193-206
25599993 Van Praet JT Commensal microbiota influence systemic autoimmune responses. EMBO J (2 015) 34:466-74
11901202 Wardemann H B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleen. J Exp Med (2 002) 195:771-80
18584871 Zou X Removal of the BiP-retention domain in Cmicro permits surface deposition and developmental progression without L-chain. Mol Immunol (2 008) 45:3573-9

EMMA ID

EM:04332

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