Stock
FESA Number
1631
Strain Name
B6.129P2(Cg)-Tlx1<tm1Thr>/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation | IMSR - unclassified |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| University of Leeds | Originator | Retained |
| University of Leeds | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Tlx1<tm1Thr> | MGI:3581680 | Tlx1 | MGI:98769 | 19 |
Phenotypic Description
Asplenia.
Publications
Displaying 1 - 8 of 8 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 15944191 | Brendolan A | A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. | Development (2 005) 132:3113-26 |
| 7555717 | Dear TN | The Hox11 gene is essential for cell survival during spleen development. | Development (1 995) 121:2909-15 |
| 11356032 | Kanzler B | Hox11 acts cell autonomously in spleen development and its absence results in altered cell fate of mesenchymal spleen precursors. | Dev Biol (2 001) 234:231-43 |
| 10822272 | Koehler K | Hox11 is required to maintain normal Wt1 mRNA levels in the developing spleen. | Dev Dyn (2 000) 218:201-6 |
| 16515781 | Moens CB | Hox cofactors in vertebrate development. | Dev Biol (2 006) 291:193-206 |
| 25599993 | Van Praet JT | Commensal microbiota influence systemic autoimmune responses. | EMBO J (2 015) 34:466-74 |
| 11901202 | Wardemann H | B-1a B cells that link the innate and adaptive immune responses are lacking in the absence of the spleen. | J Exp Med (2 002) 195:771-80 |
| 18584871 | Zou X | Removal of the BiP-retention domain in Cmicro permits surface deposition and developmental progression without L-chain. | Mol Immunol (2 008) 45:3573-9 |
EMMA ID
EM:04332
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