Stock B6.129P2(Cg)-Il1rn<tm1Nick>/Nick

FESA Number

2056

Strain Name

B6.129P2(Cg)-Il1rn<tm1Nick>/Nick

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
University of Sheffield Originator Retained
University of Sheffield Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Il1rn<tm1Nick> MGI:3038876 Il1rn MGI:96547 2

Phenotypic Description

Strain resistant to arthritis, arteritis and psoriasis (seen in BALB/c) but highly susceptible to undefined 'malaise' under conventional conditions.

Orphanet Disorders

OrphaNet ID Name Url
210 115 Sterile multifocal osteomyelitis with periostitis and pustulosis http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=210115

Publications

Displaying 1 - 8 of 8 Stock Publications
Pubmed ID Authors Title Journal
18060042 Abdollahi-Roodsaz S Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest (2 008) 118:205-16
18282478 Dewberry RM Interleukin-1 receptor antagonist (IL-1ra) modulates endothelial cell proliferation. FEBS Lett (2 008) 582:886-90
17429444 Gudjonsson JE Mouse models of psoriasis. J Invest Dermatol (2 007) 127:1292-308
20639493 Lamacchia C Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice. J Immunol (2 010) 185:2516-24
10637274 Nicklin MJ Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene. J Exp Med (2 000) 191:303-12
15939811 Shepherd J Elastic-vessel arteritis in interleukin-1 receptor antagonist-deficient mice involves effector Th1 cells and requires interleukin-1 receptor. Circulation (2 005) 111:3135-40
15086551 Shepherd J Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist. J Invest Dermatol (2 004) 122:665-9
23308180 Vecile E Intracellular function of interleukin-1 receptor antagonist in ischemic cardiomyocytes. PLoS One (2 013) 8:e53265

Orphanet Categories

Rare skin disease
Rare immune disease
Rare systemic or rheumatologic disease

EMMA ID

EM:02498

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