Stock B6.129P2(Cg)-Dazl<tm1Hjc>/H

FESA Number

3551

Strain Name

B6.129P2(Cg)-Dazl<tm1Hjc>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
MRC Human Genetics Unit Originator Retained
MRC Human Genetics Unit Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Dazl<tm1Hjc> MGI:2181904 Dazl MGI:1342328 17

Phenotypic Description

Mice homozygous for this mutation in this background lack germ cells at birth in both sexes. Heterozygous mice show close to normal fertility.

Publications

Displaying 1 - 10 of 22 Stock Publications
Pubmed ID Authors Title Journal
12360237 Cooke HJ Mouse models of male infertility. Nat Rev Genet (2 002) 3:790-801
14611631 Saunders PT Absence of mDazl produces a final block on germ cell development at meiosis. Reproduction (2 003) 126:589-97
21504946 Gill ME Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells. Proc Natl Acad Sci U S A (2 011) 108:7443-8
11514340 Schrans-Stassen BH Nature of the spermatogenic arrest in Dazl -/- mice. Biol Reprod (2 001) 65:771-6
9922113 Grootegoed JA Knockout mouse model and gametogenic failure. Mol Cell Endocrinol (1 998) 145:161-6
10393944 Slee R A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype. Proc Natl Acad Sci U S A (1 999) 96:8040-5
19468308 Haston KM Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro. PLoS One (2 009) 4:e5654
10601091 Vogel T Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype. Hum Reprod (1 999) 14:3023-9
11804965 Jiao X Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein. Biol Reprod (2 002) 66:475-85
12200456 Vogel T Partial rescue of the Dazl knockout mouse by the human DAZL gene. Mol Hum Reprod (2 002) 8:797-804

Pages

EMMA ID

EM:04536

Contact/Order

For more information or to order stocks, Contact us