Stock B6.129P2-Tln1<tm4.1Crit>/Crit

FESA Number


Strain Name


Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - congenic strain


Institution name Depositor / Originator Name
University of Leicester Originator Retained
University of Leicester Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tln1<tm4.1Crit> MGI:3770513 Tln1 MGI:1099832 4

Phenotypic Description

The homozygous floxed Tln1 mice are viable and fertile and have no phenotype.


Displaying 1 - 10 of 18 Stock Publications
Pubmed ID Authors Title Journal
18434420 Conti FJ Progressive myopathy and defects in the maintenance of myotendinous junctions in mice that lack talin 1 in skeletal muscle. Development (2 008) 135:2043-53
22075696 Wernimont SA Contact-dependent T cell activation and T cell stopping require talin1. J Immunol (2 011) 187:6256-67
19793892 Conti FJ Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions. Development (2 009) 136:3597-606
23230271 Zou W Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol (2 013) 33:830-44
20971947 Haling JR Talin-dependent integrin activation is required for fibrin clot retraction by platelets. Blood (2 011) 117:1719-22
23708969 Lämmermann T Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature (2 013) 498:371-5
18451854 Lämmermann T Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2 008) 453:51-5
22431571 Lefort CT Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2 012) 119:4275-82
20923969 Manevich-Mendelson E Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen. Blood (2 010) 116:5907-18
23266827 Manso AM Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. J Biol Chem (2 013) 288:4252-64




Genetic Status


Background Strain Name


Background Strain MGI ID



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