Stock B6.129P2-Tln1<tm4.1Crit>/Crit
FESA Number
4337
Strain Name
B6.129P2-Tln1<tm4.1Crit>/Crit
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation | IMSR - congenic strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| University of Leicester | Originator | Retained |
| University of Leicester | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Tln1<tm4.1Crit> | MGI:3770513 | Tln1 | MGI:1099832 | 4 |
Phenotypic Description
The homozygous floxed Tln1 mice are viable and fertile and have no phenotype.
Publications
Displaying 1 - 10 of 18 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 18434420 | Conti FJ | Progressive myopathy and defects in the maintenance of myotendinous junctions in mice that lack talin 1 in skeletal muscle. | Development (2 008) 135:2043-53 |
| 22075696 | Wernimont SA | Contact-dependent T cell activation and T cell stopping require talin1. | J Immunol (2 011) 187:6256-67 |
| 19793892 | Conti FJ | Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions. | Development (2 009) 136:3597-606 |
| 23230271 | Zou W | Talin1 and Rap1 are critical for osteoclast function. | Mol Cell Biol (2 013) 33:830-44 |
| 20971947 | Haling JR | Talin-dependent integrin activation is required for fibrin clot retraction by platelets. | Blood (2 011) 117:1719-22 |
| 23708969 | Lämmermann T | Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. | Nature (2 013) 498:371-5 |
| 18451854 | Lämmermann T | Rapid leukocyte migration by integrin-independent flowing and squeezing. | Nature (2 008) 453:51-5 |
| 22431571 | Lefort CT | Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. | Blood (2 012) 119:4275-82 |
| 20923969 | Manevich-Mendelson E | Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen. | Blood (2 010) 116:5907-18 |
| 23266827 | Manso AM | Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. | J Biol Chem (2 013) 288:4252-64 |
Pages
EMMA ID
EM:04999
Genetic Status
GMO
Background Strain Name
C57BL/6
Background Strain MGI ID
MGI:2159769
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