Stock
FESA Number
7114
Strain Name
B6.129P2-Tacr1/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation | IMSR - congenic strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| University College London | Originator | Retained |
| University College London | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Tacr1<tm1Sph> | MGI:2182395 | Tacr1 | MGI:98475 | 6 |
Phenotypic Description
Deletion of NK1 receptor gene. Viable, normal breeding pattern. No obvious phenotype.
Publications
Displaying 1 - 10 of 36 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 22392530 | Amadesi S | Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects. | Circulation (2 012) 125:1774-86, S1-19 |
| 23681253 | Leo D | Transgenic mouse models for ADHD. | Cell Tissue Res (2 013) 354:259-71 |
| 15499026 | Scotland RS | Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. | Circ Res (2 004) 95:1027-34 |
| 11157089 | Bester H | The NK1 receptor is essential for the full expression of noxious inhibitory controls in the mouse. | J Neurosci (2 001) 21:1039-46 |
| 15236323 | Löffler S | Increased formation of corpora lutea in neurokinin 1-receptor deficient mice. | Mol Reprod Dev (2 004) 68:408-14 |
| 14614952 | Suzuki R | The coding of noxious mechanical and thermal stimuli of deep dorsal horn neurones is attenuated in NK1 knockout mice. | Neuropharmacology (2 003) 45:1093-100 |
| 15145704 | David DJ | Serotonin transporter in substance P (neurokinin 1) receptor knock-out mice. | Eur J Pharmacol (2 004) 492:41-8 |
| 10817594 | Martinez-Caro L | Allodynia and hyperalgesia evoked by sciatic mononeuropathy in NKI receptor knockout mice. | Neuroreport (2 000) 11:1213-7 |
| 11433347 | Vergnolle N | Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. | Nat Med (2 001) 7:821-6 |
| 9537323 | De Felipe C | Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. | Nature (1 998) 392:394-7 |
Pages
EMMA ID
EM:0545
Genetic Status
GMO
Background Strain Name
C57BL/6
Background Strain MGI ID
MGI:2159769
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