Stock B6.129P2-Tacr1/H

FESA Number


Strain Name


Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - congenic strain


Institution name Depositor / Originator Name
University College London Originator Retained
University College London Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tacr1<tm1Sph> MGI:2182395 Tacr1 MGI:98475 6

Phenotypic Description

Deletion of NK1 receptor gene. Viable, normal breeding pattern. No obvious phenotype.


Displaying 1 - 10 of 36 Stock Publications
Pubmed ID Authors Title Journal
22392530 Amadesi S Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects. Circulation (2 012) 125:1774-86, S1-19
23681253 Leo D Transgenic mouse models for ADHD. Cell Tissue Res (2 013) 354:259-71
15499026 Scotland RS Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. Circ Res (2 004) 95:1027-34
11157089 Bester H The NK1 receptor is essential for the full expression of noxious inhibitory controls in the mouse. J Neurosci (2 001) 21:1039-46
15236323 Löffler S Increased formation of corpora lutea in neurokinin 1-receptor deficient mice. Mol Reprod Dev (2 004) 68:408-14
14614952 Suzuki R The coding of noxious mechanical and thermal stimuli of deep dorsal horn neurones is attenuated in NK1 knockout mice. Neuropharmacology (2 003) 45:1093-100
15145704 David DJ Serotonin transporter in substance P (neurokinin 1) receptor knock-out mice. Eur J Pharmacol (2 004) 492:41-8
10817594 Martinez-Caro L Allodynia and hyperalgesia evoked by sciatic mononeuropathy in NKI receptor knockout mice. Neuroreport (2 000) 11:1213-7
11433347 Vergnolle N Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nat Med (2 001) 7:821-6
9537323 De Felipe C Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature (1 998) 392:394-7




Genetic Status


Background Strain Name


Background Strain MGI ID



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