Stock B6.129P2-Grin1<tm1Slab>/H
FESA Number
4995
Strain Name
B6.129P2-Grin1<tm1Slab>/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation - Knock in | IMSR - congenic strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| University College London | Originator | Retained |
| University College London | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Grin1<tm1Slab> | MGI:2655224 | Grin1 | MGI:95819 | 2 |
Phenotypic Description
Heterozygous animals have subregion-specific impairment of hippocampal plasticity, associated with impaired spatial memory and navigation.
Homozygeous animals (neo/neo) die shortly after birth.
Heterozygous animals with heterozygous global Cre-mediated removal of the neo cassette (Grin1<tm1.1Slab>) die shortly after birth. Therefore the Grin1<tm1.1Slab> allele cannot be maintained.
Publications
Displaying 1 - 2 of 2 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 19794189 | Chen PE | Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus. | Learn Mem (2 009) 16:635-44 |
| 12657691 | Rudhard Y | Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. | J Neurosci (2 003) 23:2323-32 |
EMMA ID
EM:06319
Genetic Status
GMO
Background Strain Name
C57BL/6J
Background Strain MGI ID
MGI:3028467
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