Stock B6.129P2-Grin1<tm1Slab>/H

FESA Number

4995

Strain Name

B6.129P2-Grin1<tm1Slab>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation - Knock in IMSR - congenic strain

Attribution

Institution name Depositor / Originator Name
University College London Originator Retained
University College London Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Grin1<tm1Slab> MGI:2655224 Grin1 MGI:95819 2

Phenotypic Description

Heterozygous animals have subregion-specific impairment of hippocampal plasticity, associated with impaired spatial memory and navigation. Homozygeous animals (neo/neo) die shortly after birth. Heterozygous animals with heterozygous global Cre-mediated removal of the neo cassette (Grin1<tm1.1Slab>) die shortly after birth. Therefore the Grin1<tm1.1Slab> allele cannot be maintained.

Publications

Displaying 1 - 2 of 2 Stock Publications
Pubmed ID Authors Title Journal
19794189 Chen PE Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus. Learn Mem (2 009) 16:635-44
12657691 Rudhard Y Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. J Neurosci (2 003) 23:2323-32

EMMA ID

EM:06319

Genetic Status

GMO

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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