Stock

FESA Number

7812

Strain Name

B6;129P2-Chd4<tm1.1Bh>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant stock

Attribution

Institution name Depositor / Originator Name
University of Cambridge Originator Retained
University of Cambridge Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Chd4<tm1.1Bh> MGI:5775974 6

Phenotypic Description

Both heterozygotes and homozygotes for the floxed allele display no visible phenotype. Heterozygotes for the deleted allele also show no overt phenotype. Homozygotes for the deleted allele die at 3.5 dpc through a failure to develop a trophectoderm and a consequent inability to implant. This strain provides insights into how Chd4 facilitates the first lineage decision making in mammalian embryogenesis.

Publications

EMMA ID

EM:09714

Genetic Status

GMO

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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