Stock B6;129P2-Adamts1<tm1Dgen>/H
FESA Number
1843
Strain Name
B6;129P2-Adamts1<tm1Dgen>/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Targeted mutation | IMSR - mutant stock |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| Deltagen | Originator | Retained |
| Deltagen | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Adamts1<tm1Dgen> | MGI:5427602 | Adamts1 | MGI:109249 | 16 |
Phenotypic Description
No overt phenotype reported, however, kidneys seen to be enlarged and fluid-filled in 49 day homozygous mutant females and males. Weight and/or organ weight/body weight ratio increased in 49 day homozygous mutant females and males. Kidney also discoloured in 49 day homozygous mutant male. Histopathology : kidney pelvis dilated, bilateral, 49 day homozygous females and males; unilateral, 49 day homozygous female. Cortex atrophic, 49 day homozygous females and males.
MGI states that mice homozygous for targeted mutations at the Adamts1 locus that inactivate the gene display "growth retardation with adipose tissue malformation, impaired female fertility, enlarged renal calices and abnormal adrenal medullary architecture". However, impaired female fertility has not been reported in Adamts1<tm1Dgen> homozygous females.
Publications
Displaying 1 - 1 of 1 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| European Mouse Mutant Archive | Information obtained from the European Mouse Mutant Archive (EMMA) | Unpublished (2 003) : |
EMMA ID
EM:02291
Genetic Status
GMO
Background Strain Name
C57BL/6J
Background Strain MGI ID
MGI:3028467
Contact/Order
For more information or to order stocks, Contact us