Stock B6;129P2-Adamts1<tm1Dgen>/H

FESA Number


Strain Name


Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant stock


Institution name Depositor / Originator Name
Deltagen Originator Retained
Deltagen Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Adamts1<tm1Dgen> MGI:5427602 Adamts1 MGI:109249 16

Phenotypic Description

No overt phenotype reported, however, kidneys seen to be enlarged and fluid-filled in 49 day homozygous mutant females and males. Weight and/or organ weight/body weight ratio increased in 49 day homozygous mutant females and males. Kidney also discoloured in 49 day homozygous mutant male. Histopathology : kidney pelvis dilated, bilateral, 49 day homozygous females and males; unilateral, 49 day homozygous female. Cortex atrophic, 49 day homozygous females and males. MGI states that mice homozygous for targeted mutations at the Adamts1 locus that inactivate the gene display "growth retardation with adipose tissue malformation, impaired female fertility, enlarged renal calices and abnormal adrenal medullary architecture". However, impaired female fertility has not been reported in Adamts1<tm1Dgen> homozygous females.


Displaying 1 - 1 of 1 Stock Publications
Pubmed ID Authors Title Journal
European Mouse Mutant Archive Information obtained from the European Mouse Mutant Archive (EMMA) Unpublished (2 003) :



Genetic Status


Background Strain Name


Background Strain MGI ID



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