Mutation Strain Type
|Institution name||Depositor / Originator||Name|
No overt phenotype reported, however, kidneys seen to be enlarged and fluid-filled in 49 day homozygous mutant females and males. Weight and/or organ weight/body weight ratio increased in 49 day homozygous mutant females and males. Kidney also discoloured in 49 day homozygous mutant male. Histopathology : kidney pelvis dilated, bilateral, 49 day homozygous females and males; unilateral, 49 day homozygous female. Cortex atrophic, 49 day homozygous females and males. MGI states that mice homozygous for targeted mutations at the Adamts1 locus that inactivate the gene display "growth retardation with adipose tissue malformation, impaired female fertility, enlarged renal calices and abnormal adrenal medullary architecture". However, impaired female fertility has not been reported in Adamts1<tm1Dgen> homozygous females.