Stock B6;129P2-Adamts1<tm1Dgen>/H

FESA Number

1843

Strain Name

B6;129P2-Adamts1<tm1Dgen>/H

Mutation Strain Type

Attribution

Institution name Depositor / Originator Name
Deltagen Originator Retained
Deltagen Depositor Retained

Phenotypic Description

No overt phenotype reported, however, kidneys seen to be enlarged and fluid-filled in 49 day homozygous mutant females and males. Weight and/or organ weight/body weight ratio increased in 49 day homozygous mutant females and males. Kidney also discoloured in 49 day homozygous mutant male. Histopathology : kidney pelvis dilated, bilateral, 49 day homozygous females and males; unilateral, 49 day homozygous female. Cortex atrophic, 49 day homozygous females and males. MGI states that mice homozygous for targeted mutations at the Adamts1 locus that inactivate the gene display "growth retardation with adipose tissue malformation, impaired female fertility, enlarged renal calices and abnormal adrenal medullary architecture". However, impaired female fertility has not been reported in Adamts1<tm1Dgen> homozygous females.

Publications

EMMA ID

EM:02291

Genetic Status

GMO

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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