Stock

FESA Number

3500

Strain Name

B6.129-Scn10a<tm2(cre)Jnw>/H

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Scn10a<tm2(cre)Jnw> MGI:3053096 Scn10a MGI:108029 9

Phenotypic Description

No phenotype in heterozygotes. Some pain deficits in homozygotes.

Publications

Displaying 21 - 28 of 28 Stock Publications
Pubmed ID Authors Title Journal
24440715 Minett MS Pain without nociceptors? Nav1.7-independent pain mechanisms. Cell Rep (2 014) 6:301-12
24216512 Zhao ZQ Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest (2 013) 123:4769-80
22531176 Minett MS Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. Nat Commun (2 012) 3:791
25453842 Zhao ZQ Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling. Neuron (2 014) 84:821-34
17052333 Nassar MA Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice. Mol Pain (2 006) 2:33
15314237 Nassar MA Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A (2 004) 101:12706-11
24305821 Persson AK Sodium channels contribute to degeneration of dorsal root ganglion neurites induced by mitochondrial dysfunction in an in vitro model of axonal injury. J Neurosci (2 013) 33:19250-61
24759321 Riol-Blanco L Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation. Nature (2 014) 510:157-61

Pages

EMMA ID

EM:04582

Genetic Status

GMO

Production Information

Cre-Lox Recombination based excision

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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