Stock

FESA Number

3500

Strain Name

B6.129-Scn10a<tm2(cre)Jnw>/H

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Scn10a<tm2(cre)Jnw> MGI:3053096 Scn10a MGI:108029 9

Phenotypic Description

No phenotype in heterozygotes. Some pain deficits in homozygotes.

Publications

Displaying 11 - 20 of 28 Stock Publications
Pubmed ID Authors Title Journal
19535578 Fricker FR Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance. J Neurosci (2 009) 29:7667-78
18498735 Wickramasinghe SR Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron (2 008) 58:532-45
21618224 Gautron L Genetic tracing of Nav1.8-expressing vagal afferents in the mouse. J Comp Neurol (2 011) 519:3085-101
20609517 Willemen HL Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling. Pain (2 010) 150:550-60
21295407 Gaveriaux-Ruff C Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain (2 011) 152:1238-48
20702715 Zhao J Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds. J Neurosci (2 010) 30:10860-71
21040852 Lagerström MC VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Neuron (2 010) 68:529-42
16413788 Zhao J Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain. Mol Cell Neurosci (2 006) 31:539-48
21415372 Lagerström MC A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain. Proc Natl Acad Sci U S A (2 011) 108:5789-94
21059214 Zhao J Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain. Mol Pain (2 010) 6:77

Pages

EMMA ID

EM:04582

Genetic Status

GMO

Production Information

Cre-Lox Recombination based excision

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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