Stock B6.129-Scn10a<tm2(cre)Jnw>/H

FESA Number

7898

Strain Name

B6.129-Scn10a<tm2(cre)Jnw>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - congenic strain

Attribution

Institution name Depositor / Originator Name
University College London Originator Retained
University College London Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Scn10a<tm2(cre)Jnw> MGI:3053096 Scn10a MGI:108029 9

Phenotypic Description

No phenotype in heterozygotes. Some pain deficits in homozygotes.

Publications

Displaying 1 - 10 of 28 Stock Publications
Pubmed ID Authors Title Journal
18669863 Abrahamsen B The cell and molecular basis of mechanical, cold, and inflammatory pain. Science (2 008) 321:702-5
22875917 Shields SD Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury. J Neurosci (2 012) 32:10819-32
24259584 Daou I Remote optogenetic activation and sensitization of pain pathways in freely moving mice. J Neurosci (2 013) 33:18631-40
22703890 Shields SD Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system. Pain (2 012) 153:2017-30
20147541 Eijkelkamp N GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain. J Neurosci (2 010) 30:2138-49
23433317 Sorge RE The Yin and Yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene. Genes Brain Behav (2 013) 12:405-13
21903816 Emery EC HCN2 ion channels play a central role in inflammatory and neuropathic pain. Science (2 011) 333:1462-6
15621361 Stirling LC Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice. Pain (2 005) 113:27-36
17035534 Foulkes T Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior. J Neurosci (2 006) 26:10499-507
24069332 Weibel R Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice. PLoS One (2 013) 8:e74706

Pages

EMMA ID

EM:04582

Genetic Status

GMO

Production Information

Cre-Lox Recombination based excision

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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