Stock

FESA Number

1622

Strain Name

B6;129-Ptprc<tm1Holm>/H

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Ptprc<tm1Holm> MGI:1857277 Ptprc MGI:97810 1

Phenotypic Description

Defective lymphocyte development, more severe in T lineage, severe combined immunodeficiency.

Orphanet Disorders

OrphaNet ID Name Url
169 157 T-B+ severe combined immunodeficiency due to CD45 deficiency http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=169157

Publications

Displaying 21 - 27 of 27 Stock Publications
Pubmed ID Authors Title Journal
15557316 López MC Phenotypical and functional alterations in the mucosal immune system of CD45 exon 9 KO mice. Int Immunol (2 005) 17:15-25
21273420 Zhu Y CD45 deficiency drives amyloid-? peptide oligomers and neuronal loss in Alzheimer's disease mice. J Neurosci (2 011) 31:1355-65
11342624 Martin SM Development of intestinal intraepithelial lymphocytes, NK cells, and NK 1.1+ T cells in CD45-deficient mice. J Immunol (2 001) 166:6066-73
17719247 McNeill L The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses. Immunity (2 007) 27:425-37
16856204 Montoya M CD45 is required for type I IFN production by dendritic cells. Eur J Immunol (2 006) 36:2150-8
12902479 Ogilvy S Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice. J Immunol (2 003) 171:1792-800
19269962 Panchal RG Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis. J Biol Chem (2 009) 284:12874-85

Pages

Orphanet Categories

Rare immune disease

EMMA ID

EM:01736

Genetic Status

GMO

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