Stock B6.129-Nrxn2<tm1Sud>/H

FESA Number

5665

Strain Name

B6.129-Nrxn2<tm1Sud>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
Unknown Institution Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Nrxn2<tm1Sud> MGI:3042719 Nrxn2 MGI:1096362 19

Phenotypic Description

Mice homozygous for a knock-out allele show a 30-40% decrease in body weight and their inhibitory postsynaptic currents (IPSCs) are decreased in cortical slice cultures. Further phenotyping data to be published shortly.

Publications

Displaying 1 - 6 of 6 Stock Publications
Pubmed ID Authors Title Journal
25423136 Dachtler J Deletion of ?-neurexin II results in autism-related behaviors in mice. Transl Psychiatry (2 014) 4:e484
17347997 Dudanova I Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation. J Comp Neurol (2 007) 502:261-74
17035546 Dudanova I Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules. J Neurosci (2 006) 26:10599-613
14983056 Kattenstroth G Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins. Proc Natl Acad Sci U S A (2 004) 101:2607-12
12827191 Missler M Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature (2 003) 423:939-48
16406382 Sons MS alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction. Neuroscience (2 006) 138:433-46

EMMA ID

EM:06876

Genetic Status

GMO

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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