Stock B6;129-Gt(ROSA)26Sor<tm1(CAG-Venus/GMNN,Cherry/CDT1)Jkn>/JknH

FESA Number

6899

Strain Name

B6;129-Gt(ROSA)26Sor<tm1(CAG-Venus/GMNN,Cherry/CDT1)Jkn>/JknH

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant stock

Attribution

Institution name Depositor / Originator Name
MRC Human Genetics Unit Originator Retained
MRC Human Genetics Unit Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Gt(ROSA)26Sor<tm1(CAG-Venus/GMNN,-Cherry/CDT1)Jkn> MGI:5645798 Gt(ROSA)26Sor MGI:104735 6

Phenotypic Description

The Fucci system was developed by fusing red- and green-emitting fluorescent proteins to the E3 ligase substrates, Cdt1 and Geminin. These fluorescent probes make it possible to distinguish between cells in the G1 or S/G2/M phases of the cell cycle in live cells/tissue (Sakaue-Sawano al 2008). Fucci2a is a bicistronic version of Fucci2 allowing Cre-mediated tissue-specific expression in mice (Mort, R et al 2014).

Publications

Displaying 1 - 10 of 88 Stock Publications
Pubmed ID Authors Title Journal
16982747 Aghi M Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer Res (2 006) 66:9054-64
20864684 Choi J Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency. Am J Pathol (2 010) 177:2645-58
18535290 Ho KJ Optimized adeno-associated virus 8 produces hepatocyte-specific Cre-mediated recombination without toxicity or affecting liver regeneration. Am J Physiol Gastrointest Liver Physiol (2 008) 295:G412-9
19229337 Medina-Martinez O Cell-autonomous requirement for rx function in the mammalian retina and posterior pituitary. PLoS One (2 009) 4:e4513
17882221 Seandel M Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature (2 007) 449:346-50
17229766 Ybot-Gonzalez P Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development (2 007) 134:789-99
18328424 Ahn GO Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell (2 008) 13:193-205
17369357 Ciarloni L Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Proc Natl Acad Sci U S A (2 007) 104:5455-60
16039563 Hoshino M Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron (2 005) 47:201-13
21173232 Montgomery RK Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A (2 011) 108:179-84

Pages

EMMA ID

EM:08395

Genetic Status

GMO

Background Strain Name

C57BL/6

Background Strain MGI ID

MGI:2159769

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