Mutation Strain Type
|Institution name||Depositor / Originator||Name|
|MRC Human Genetics Unit||Originator||Retained|
|MRC Human Genetics Unit||Depositor||Retained|
The Fucci system was developed by fusing red- and green-emitting fluorescent proteins to the E3 ligase substrates, Cdt1 and Geminin. These fluorescent probes make it possible to distinguish between cells in the G1 or S/G2/M phases of the cell cycle in live cells/tissue (Sakaue-Sawano al 2008). Fucci2a is a bicistronic version of Fucci2 allowing Cre-mediated tissue-specific expression in mice (Mort, R et al 2014).