Stock B6;129-Fshr<tm1Mha>/H

FESA Number


Strain Name


Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant strain


Institution name Depositor / Originator Name
University of Oxford Originator Retained
University of Oxford Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Fshr<tm1Mha> MGI:2384130 Fshr MGI:95583 17

Phenotypic Description

Homozygous males are fertile, but testis weight is reduced (~50% of normal). Homozygous females are infertile, ovulation does not occur. Heterozygous males are indistinguishable from wild type.

Orphanet Disorders

OrphaNet ID Name Url
243 46,XX gonadal dysgenesis
64 739 Ovarian hyperstimulation syndrome


Displaying 1 - 7 of 7 Stock Publications
Pubmed ID Authors Title Journal
10803590 Abel MH The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction. Endocrinology (2 000) 141:1795-803
18403489 Abel MH Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen. Endocrinology (2 008) 149:3279-85
12578530 Abel MH Age-related uterine and ovarian hypertrophy in FSH receptor knockout and FSHbeta subunit knockout mice. Reproduction (2 003) 125:165-73
12488339 Baker PJ Failure of normal Leydig cell development in follicle-stimulating hormone (FSH) receptor-deficient mice, but not FSHbeta-deficient mice: role for constitutive FSH receptor activity. Endocrinology (2 003) 144:138-45
16416028 Choi Y Genetics of early mammalian folliculogenesis. Cell Mol Life Sci (2 006) 63:579-90
15232063 Hirst RC Influence of mutations affecting gonadotropin production or responsiveness on expression of inhibin subunit mRNA and protein in the mouse ovary. Reproduction (2 004) 128:43-52
14551232 Johnston H Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse. Endocrinology (2 004) 145:318-29

Orphanet Categories

Rare developmental defect during embryogenesis
Rare urogenital disease
Rare endocrine disease
Rare gynecologic or obstetric disease




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