Stock B6;129-Fshr<tm1Mha>/H

FESA Number

4282

Strain Name

B6;129-Fshr<tm1Mha>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
University of Oxford Originator Retained
University of Oxford Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Fshr<tm1Mha> MGI:2384130 Fshr MGI:95583 17

Phenotypic Description

Homozygous males are fertile, but testis weight is reduced (~50% of normal). Homozygous females are infertile, ovulation does not occur. Heterozygous males are indistinguishable from wild type.

Orphanet Disorders

OrphaNet ID Name Url
243 46,XX gonadal dysgenesis http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=243
64 739 Ovarian hyperstimulation syndrome http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=64739

Publications

Displaying 1 - 7 of 7 Stock Publications
Pubmed ID Authors Title Journal
10803590 Abel MH The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction. Endocrinology (2 000) 141:1795-803
18403489 Abel MH Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen. Endocrinology (2 008) 149:3279-85
12578530 Abel MH Age-related uterine and ovarian hypertrophy in FSH receptor knockout and FSHbeta subunit knockout mice. Reproduction (2 003) 125:165-73
12488339 Baker PJ Failure of normal Leydig cell development in follicle-stimulating hormone (FSH) receptor-deficient mice, but not FSHbeta-deficient mice: role for constitutive FSH receptor activity. Endocrinology (2 003) 144:138-45
16416028 Choi Y Genetics of early mammalian folliculogenesis. Cell Mol Life Sci (2 006) 63:579-90
15232063 Hirst RC Influence of mutations affecting gonadotropin production or responsiveness on expression of inhibin subunit mRNA and protein in the mouse ovary. Reproduction (2 004) 128:43-52
14551232 Johnston H Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse. Endocrinology (2 004) 145:318-29

Orphanet Categories

Rare developmental defect during embryogenesis
Rare urogenital disease
Rare endocrine disease
Rare gynecologic or obstetric disease

EMMA ID

EM:04913

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