Stock B6.129-Flrt2<tm1Rob>/RobH

FESA Number

6827

Strain Name

B6.129-Flrt2<tm1Rob>/RobH

Mutation Strain Type

Attribution

Institution name Depositor / Originator Name
University of Oxford Originator Retained
University of Oxford Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Flrt2<tm1Rob> MGI:4950410 Flrt2 MGI:3603594 12

Phenotypic Description

Mouse embryos deficient in Flrt2 display defects in heart morphogenesis, in particular, defects in the integrity of the epicardium and disturbances to the architecture of the underlying basement membrane accompanied by a pronounced reduction in thickness of the ventricular myocardium. A small proportion of homozygous mutants survive gestation (<3%). Heterozygous mice have no overt phenotype.

Publications

Displaying 1 - 1 of 1 Stock Publications
Pubmed ID Authors Title Journal
21350012 Müller PS The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis. Development (2 011) 138:1297-308

EMMA ID

EM:08321

Genetic Status

GMO

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

Contact/Order

For more information or to order stocks, Contact us