Mutation Strain Type
|Institution name||Depositor / Originator||Name|
|University of Oxford||Originator||Retained|
|University of Oxford||Depositor||Retained|
Mouse embryos deficient in Flrt2 display defects in heart morphogenesis, in particular, defects in the integrity of the epicardium and disturbances to the architecture of the underlying basement membrane accompanied by a pronounced reduction in thickness of the ventricular myocardium. A small proportion of homozygous mutants survive gestation (<3%). Heterozygous mice have no overt phenotype.