Stock B6.129-Flrt2<tm1Rob>/RobH

FESA Number

6827

Strain Name

B6.129-Flrt2<tm1Rob>/RobH

Mutation Strain Type

Attribution

Institution name Depositor / Originator Name
University of Oxford Originator Retained
University of Oxford Depositor Retained

Phenotypic Description

Mouse embryos deficient in Flrt2 display defects in heart morphogenesis, in particular, defects in the integrity of the epicardium and disturbances to the architecture of the underlying basement membrane accompanied by a pronounced reduction in thickness of the ventricular myocardium. A small proportion of homozygous mutants survive gestation (<3%). Heterozygous mice have no overt phenotype.

Publications

EMMA ID

EM:08321

Genetic Status

GMO

Background Strain Name

C57BL/6J

Background Strain MGI ID

MGI:3028467

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