Stock

FESA Number

1638

Strain Name

B10.Cg-H2<k2> Tg(CD2-Ptpn11*C459S)1Axdr/AxdrH

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Transgenic IMSR - unclassified

Attribution

Institution name Depositor / Originator Name
Babraham Institute Originator Retained
Babraham Institute Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tg(CD2-Ptpn11*C459S)1Axdr MGI:5310938 Tg(CD2-Ptpn11*C459S)1Axdr MGI:5310889
H2<k> MGI:3579322 H2 MGI:95894 17

Phenotypic Description

Characterisation of phenotype still in progress but line displays defective primary immune responses to T-dependent antigen and amplified cytokine secretion in response to antgenic challenge.

Publications

Displaying 1 - 2 of 2 Stock Publications
Pubmed ID Authors Title Journal
16272304 Salmond RJ The src homology 2 domain-containing tyrosine phosphatase 2 regulates primary T-dependent immune responses and Th cell differentiation. J Immunol (2 005) 175:6498-508
7665895 Zhumabekov T Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J Immunol Methods (1 995) 185:133-40

EMMA ID

EM:01734

Genetic Status

GMO

Background Strain Name

C57BL/10

Background Strain MGI ID

MGI:2159788

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