Stock 129S2.Cg-Tg(KRT10-Igfr2*)KippsGfc/H
FESA Number
3546
Strain Name
129S2.Cg-Tg(KRT10-Igfr2*)KippsGfc/H
Mutation Strain Type
| Mutation Type | Mutation Subtype | Strain Type |
|---|---|---|
| IMSR - Transgenic | IMSR - mutant strain |
Attribution
| Institution name | Depositor / Originator | Name |
|---|---|---|
| University of Oxford | Originator | Retained |
| University of Oxford | Depositor | Retained |
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Tg(KRT10-Igf2r*)KippsGfc | MGI:5436057 |
Phenotypic Description
Slightly reduced overall body weight, disproportionate reduction in size of alimentary canal and uterus.
Publications
Displaying 1 - 3 of 3 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 16488992 | Harper J | Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting. | Cancer Res (2 006) 66:1940-8 |
| 9724044 | Zaina S | Local reduction of organ size in transgenic mice expressing a soluble insulin-like growth factor II/mannose-6-phosphate receptor. | Endocrinology (1 998) 139:3886-95 |
| 9786853 | Zaina S | The soluble type 2 insulin-like growth factor (IGF-II) receptor reduces organ size by IGF-II-mediated and IGF-II-independent mechanisms. | J Biol Chem (1 998) 273:28610-6 |
EMMA ID
EM:04336
Background Strain Name
129S2/SvPas
Background Strain MGI ID
MGI:2161070
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