Stock

FESA Number

5653

Strain Name

129S2(B6)-Meg3<Gt(pGTi)216Gos>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Gene Trap IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
University of Cambridge Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Meg3<Gt(pGTi)216Gos> MGI:2177961 Meg3 MGI:1202886 12

Severity Limit

Mild

Phenotypic Description

Imprinted dwarfism and thyroid hormone defects. This transgenic mouse line carries an insertional mutation with a dominant modified pattern of inheritance: heterozygous Gtl2 lacZ mice that inherited the transgene from the father show a proportionate dwarfism phenotype; whereas the penetrance and expressivity of the phenotype is strongly reduced in Gtl2 lacZ mice that inherited the transgene from the mother. On a mixed genetic background this pattern of inheritance was reversible upon transmission of the transgene through the germ line of the opposite sex whereas on a predominantly 129S2/SvPas genetic background the transgene passage through the female germ line modifies the transgene effect, such that the penetrance of the mutation was drastically reduced and the phenotype is no longer obvious after subsequent male germ line transmission. Expression of the transgene is neither affected by genetic background nor by parental legacy. It has been postulated that that the transgene insertion in Gtl2 lacZ mice affects an endogenous gene(s) required for fetal and postnatal growth and that this gene(s) is predominantly paternally expressed.

Publications

Displaying 1 - 7 of 7 Stock Publications
Pubmed ID Authors Title Journal
24034272 Charalambous M Perturbations to the IGF1 growth pathway and adult energy homeostasis following disruption of mouse chromosome 12 imprinting. Acta Physiol (Oxf) (2 014) 210:174-87
22326222 Charalambous M Imprinted gene dosage is critical for the transition to independent life. Cell Metab (2 012) 15:209-21
15163367 Peters J Identification and characterisation of imprinted genes in the mouse. Brief Funct Genomic Proteomic (2 004) 2:320-33
9626496 Schuster-Gossler K The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA. Dev Dyn (1 998) 212:214-28
8903723 Schuster-Gossler K Gtl2lacZ, an insertional mutation on mouse chromosome 12 with parental origin-dependent phenotype. Mamm Genome (1 996) 7:20-4
16575184 Sekita Y Aberrant regulation of imprinted gene expression in Gtl2lacZ mice. Cytogenet Genome Res (2 006) 113:223-9
17014736 Steshina EY Loss of imprinting at the Dlk1-Gtl2 locus caused by insertional mutagenesis in the Gtl2 5' region. BMC Genet (2 006) 7:44

EMMA ID

EM:06878

Genetic Status

GMO

Background Strain Name

129S2/SvPas

Background Strain MGI ID

MGI:2161070

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