Mutation Strain Type
|Institution name||Depositor / Originator||Name|
|University of Cambridge||Depositor||Retained|
Imprinted dwarfism and thyroid hormone defects. This transgenic mouse line carries an insertional mutation with a dominant modified pattern of inheritance: heterozygous Gtl2 lacZ mice that inherited the transgene from the father show a proportionate dwarfism phenotype; whereas the penetrance and expressivity of the phenotype is strongly reduced in Gtl2 lacZ mice that inherited the transgene from the mother. On a mixed genetic background this pattern of inheritance was reversible upon transmission of the transgene through the germ line of the opposite sex whereas on a predominantly 129S2/SvPas genetic background the transgene passage through the female germ line modifies the transgene effect, such that the penetrance of the mutation was drastically reduced and the phenotype is no longer obvious after subsequent male germ line transmission. Expression of the transgene is neither affected by genetic background nor by parental legacy. It has been postulated that that the transgene insertion in Gtl2 lacZ mice affects an endogenous gene(s) required for fetal and postnatal growth and that this gene(s) is predominantly paternally expressed.