Stock

FESA Number

4143

Strain Name

129P2/OlaHsd-Wt1<tm1Mlh>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - unclassified

Attribution

Institution name Depositor / Originator Name
University of Newcastle Originator Retained
University of Newcastle Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Wt1<tm1Mlh> MGI:3794650 Wt1 MGI:98968 2

Phenotypic Description

Heterozygous mutant mice develop glomerulosclerosis (typical of Denys Drash Syndrome) with age.

Orphanet Disorders

OrphaNet ID Name Url
893 WAGR syndrome http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=893
654 Nephroblastoma http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=654
251 510 46,XY partial gonadal dysgenesis http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=251510
3 097 Meacham syndrome http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=3097
220 Denys-Drash syndrome http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=220
347 Frasier syndrome http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=347
93 220 Sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=93220
93 217 Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=93217
93 213 Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=93213
83 469 Desmoplastic small round cell tumor http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=83469

Publications

Displaying 1 - 1 of 1 Stock Publications
Pubmed ID Authors Title Journal
18040647 Patek CE Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396). Transgenic Res (2 008) 17:459-75

Orphanet Categories

Rare developmental defect during embryogenesis
Rare urogenital disease
Rare renal disease
Rare eye disease
Rare endocrine disease
Rare oncologic disease
Rare gynecologic or obstetric disease
Rare abdominal surgical disease

EMMA ID

EM:04835

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