Stock 129P2-Gal<tm1Wyn>/WynH

FESA Number


Strain Name


Mutation Strain Type


Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Gal<tm1Wyn> MGI:2183172 Gal MGI:95637 19

Phenotypic Description

Developmental deficits in DRG and cholinergic neurons, absence of neuropathic pain, deficits in neuronal regeneration and neurite outgrowth and more severe disease in EAE model of MS and A-beta model of AD


Displaying 11 - 20 of 26 Stock Publications
Pubmed ID Authors Title Journal
15934937 Hawes JJ GalR1, but not GalR2 or GalR3, levels are regulated by galanin signaling in the locus coeruleus through a cyclic AMP-dependent mechanism. J Neurochem (2 005) 93:1168-76
11016971 O'Meara G Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A (2 000) 97:11569-74
15024085 Hohmann JG Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin. Mol Cell Biol (2 004) 24:2978-85
17921877 Sachs HH Galanin plays a role in the conditioning lesion effect in sensory neurons. Neuroreport (2 007) 18:1729-33
12845222 Hohmann JG Neuroendocrine profiles in galanin-overexpressing and knockout mice. Neuroendocrinology (2 003) 77:354-66
19717462 Wraith DC A role for galanin in human and experimental inflammatory demyelination. Proc Natl Acad Sci U S A (2 009) 106:15466-71
12605897 Hohmann JG Distribution and regulation of galanin receptor 1 messenger RNA in the forebrain of wild type and galanin-transgenic mice. Neuroscience (2 003) 117:105-17
9770544 Wynick D Galanin regulates prolactin release and lactotroph proliferation. Proc Natl Acad Sci U S A (1 998) 95:12671-6
11016970 Holmes FE Targeted disruption of the galanin gene reduces the number of sensory neurons and their regenerative capacity. Proc Natl Acad Sci U S A (2 000) 97:11563-8
12853567 Zachariou V The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal. Proc Natl Acad Sci U S A (2 003) 100:9028-33




Genetic Status


Background Strain Name


Background Strain MGI ID



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