Stock 129P2-Gal<tm1Wyn>/WynH

FESA Number

6703

Strain Name

129P2-Gal<tm1Wyn>/WynH

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant strain

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
Unknown Institution Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Gal<tm1Wyn> MGI:2183172 Gal MGI:95637 19

Phenotypic Description

Developmental deficits in DRG and cholinergic neurons, absence of neuropathic pain, deficits in neuronal regeneration and neurite outgrowth and more severe disease in EAE model of MS and A-beta model of AD

Publications

Displaying 1 - 10 of 26 Stock Publications
Pubmed ID Authors Title Journal
18088361 Adams AC Feeding behaviour in galanin knockout mice supports a role of galanin in fat intake and preference. J Neuroendocrinol (2 008) 20:199-206
12533601 Mahoney SA The second galanin receptor GalR2 plays a key role in neurite outgrowth from adult sensory neurons. J Neurosci (2 003) 23:416-21
15044363 Ahrén B Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice. Endocrinology (2 004) 145:3190-6
12559120 Massey PV Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex. Neuropharmacology (2 003) 44:40-8
24726665 Cordero-Llana O Galanin promotes neuronal differentiation from neural progenitor cells in vitro and contributes to the generation of new olfactory neurons in the adult mouse brain. Exp Neurol (2 014) 256:93-104
10934278 Mazarati AM Modulation of hippocampal excitability and seizures by galanin. J Neurosci (2 000) 20:6276-81
15041741 Elliott-Hunt CR Galanin acts as a neuroprotective factor to the hippocampus. Proc Natl Acad Sci U S A (2 004) 101:5105-10
11063342 McKenzie IF Fucosyl transferase (H) transgenic heart transplants to Gal-/- mice. Transplantation (2 000) 70:1205-9
25639936 Gresle MM Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor. Glia (2 015) 63:1005-20
12759342 Naylor MJ The neuropeptide galanin augments lobuloalveolar development. J Biol Chem (2 003) 278:29145-52

Pages

EMMA ID

EM:08194

Genetic Status

GMO

Background Strain Name

129P2/OlaHsd

Background Strain MGI ID

MGI:2164147

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