Stock

FESA Number

6553

Strain Name

129(Cg)-Tecta<tm5.1Gpr>/GprH

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation IMSR - mutant stock

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
Unknown Institution Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Tecta<tm5.1Gpr> MGI:5527096 Tecta MGI:109575 9

Phenotypic Description

In Tecta<tm5.1Gpr>/<tm5.1Gpr> homozygotes the tectorial membrane is completely detached from the spiral limbus and is associated instead with the Reissner membrane. Tecta is virtually undetectable by immunofluorescence in the detached tectorial membrane, with the exception of some weak labelling at the extreme apical end. In heterozygous mice inner ear phenotype shows malformation of the tectorial membrane, ABR thresholds elevated by ~35 dB and an enhanced susceptibility to audiogenic seizure at low sound pressure levels. See PubMed 24363064 Legan et al Human Mol Genet 2013: Three deaf mice.

Publications

Displaying 1 - 1 of 1 Stock Publications
Pubmed ID Authors Title Journal
24363064 Legan PK Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane. Hum Mol Genet (2 014) 23:2551-68

EMMA ID

EM:08020

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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