Mutation Strain Type
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In Tecta<tm5.1Gpr>/<tm5.1Gpr> homozygotes the tectorial membrane is completely detached from the spiral limbus and is associated instead with the Reissner membrane. Tecta is virtually undetectable by immunofluorescence in the detached tectorial membrane, with the exception of some weak labelling at the extreme apical end. In heterozygous mice inner ear phenotype shows malformation of the tectorial membrane, ABR thresholds elevated by ~35 dB and an enhanced susceptibility to audiogenic seizure at low sound pressure levels. See PubMed 24363064 Legan et al Human Mol Genet 2013: Three deaf mice.