Stock

FESA Number

5729

Strain Name

129(B6)-Thy1<tm1Rjmo>/H

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Thy1<tm1Rjmo> MGI:3586862 Thy1 MGI:98747 9

Phenotypic Description

Nervous system: reduced long term potentiation (J:31610). Strong inhibition of LTP in the dentate gyrus but not in CA1, however spatial learning as assessed in the watermaze is unimpaired. Respiratory system: pulmonary fibrosis (J:99951). Marked increase in severity of lung fibrosis and more extensive collagen deposition in response to intratracheal bleomycin, compared to controls.

Publications

Displaying 11 - 15 of 15 Stock Publications
Pubmed ID Authors Title Journal
21264853 Schubert K Thy-1 (CD90) regulates the extravasation of leukocytes during inflammation. Eur J Immunol (2 011) 41:645-56
10567740 Simon PD Thy-1 is critical for normal retinal development. Brain Res Dev Brain Res (1 999) 117:219-23
22268140 Varisco BM Thy-1 signals through PPAR? to promote lipofibroblast differentiation in the developing lung. Am J Respir Cell Mol Biol (2 012) 46:765-72
25416548 Woeller CF Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn. FASEB J (2 015) 29:920-31
19056849 Zhou Y Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin. Am J Pathol (2 009) 174:21-33

Pages

EMMA ID

EM:07002

Genetic Status

GMO

Background Strain Name

129S/SvEv

Background Strain MGI ID

MGI:3050593

Strain Sanitary Status

None (however, the unit does not exclude MNV and Helicobacter).

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