Stock

FESA Number

5729

Strain Name

129(B6)-Thy1<tm1Rjmo>/H

Mutation Strain Type

Mutation Type Mutation Subtype Strain Type
IMSR - Targeted mutation - Knock out IMSR - mutant stock

Attribution

Institution name Depositor / Originator Name
Unknown Institution Originator Retained
Unknown Institution Depositor Retained

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Thy1<tm1Rjmo> MGI:3586862 Thy1 MGI:98747 9

Phenotypic Description

Nervous system: reduced long term potentiation (J:31610). Strong inhibition of LTP in the dentate gyrus but not in CA1, however spatial learning as assessed in the watermaze is unimpaired. Respiratory system: pulmonary fibrosis (J:99951). Marked increase in severity of lung fibrosis and more extensive collagen deposition in response to intratracheal bleomycin, compared to controls.

Publications

Displaying 1 - 10 of 15 Stock Publications
Pubmed ID Authors Title Journal
9820502 Beissert S Impaired cutaneous immune responses in Thy-1-deficient mice. J Immunol (1 998) 161:5296-302
18676775 Cohen PY Thy1 up-regulates FasL expression in lung myofibroblasts via Src family kinases. Am J Respir Cell Mol Biol (2 009) 40:231-8
16049324 Hagood JS Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. Am J Pathol (2 005) 167:365-79
9285719 Hueber AO Thymocytes in Thy-1-/- mice show augmented TCR signaling and impaired differentiation. Curr Biol (1 997) 7:705-8
10662668 Mayeux-Portas V Mice lacking the cell adhesion molecule Thy-1 fail to use socially transmitted cues to direct their choice of food. Curr Biol (2 000) 10:68-75
19270178 Nicola T Loss of Thy-1 inhibits alveolar development in the newborn mouse lung. Am J Physiol Lung Cell Mol Physiol (2 009) 296:L738-50
8587606 Nosten-Bertrand M Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1. Nature (1 996) 379:826-9
9548467 Page DM Role of Thy-1 in T cell development. J Immunol (1 997) 159:5285-92
25739049 Schmidt M Controlling the Balance of Fibroblast Proliferation and Differentiation: Impact of Thy-1. J Invest Dermatol (2 015) 135:1893-902
23159525 Schubert K Melanoma cells use Thy-1 (CD90) on endothelial cells for metastasis formation. Am J Pathol (2 013) 182:266-76

Pages

EMMA ID

EM:07002

Genetic Status

GMO

Background Strain Name

129S/SvEv

Background Strain MGI ID

MGI:3050593

Strain Sanitary Status

None (however, the unit does not exclude MNV and Helicobacter).

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