Stock

FESA Number

2899

Strain Name

129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Serpine1<tm1Mlg> MGI:1857287 Serpine1 MGI:97608 5

Phenotypic Description

Shortened life span.

Orphanet Disorders

OrphaNet ID Name Url
465 Congenital plasminogen activator inhibitor type 1 deficiency http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465

Publications

Displaying 81 - 90 of 229 Stock Publications
Pubmed ID Authors Title Journal
21042583 Stein S ApoE-/- PGC-1?-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. PLoS One (2 010) 5:e13539
9486990 Xiao Q Fibrinogen deficiency is compatible with the development of atherosclerosis in mice. J Clin Invest (1 998) 101:1184-94
18469330 Bajt ML Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose. Toxicol Sci (2 008) 104:419-27
21734232 Courey AJ The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice. Blood (2 011) 118:2313-21
17652357 Harslund J Gender-dependent physiological implications of combined PAI-1 and TIMP-1 gene deficiency characterized in a mouse model. Am J Physiol Regul Integr Comp Physiol (2 007) 293:R1630-9
15716324 Koh TJ Mice deficient in plasminogen activator inhibitor-1 have improved skeletal muscle regeneration. Am J Physiol Cell Physiol (2 005) 289:C217-23
16528256 Ma J Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury. Kidney Int (2 006) 69:1064-72
23940734 Omouendze PL Hypoxia-ischemia or excitotoxin-induced tissue plasminogen activator- dependent gelatinase activation in mice neonate brain microvessels. PLoS One (2 013) 8:e71263
15944322 Sejima T Protection of plasminogen activator inhibitor-1-deficient mice from nasal allergy. J Immunol (2 005) 174:8135-43
18197246 Bhasin JM Sex specific gene regulation and expression QTLs in mouse macrophages from a strain intercross. PLoS One (2 008) 3:e1435

Pages

Orphanet Categories

Rare hematologic disease

EMMA ID

EM:02066

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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