Stock
FESA Number
2899
Strain Name
129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]
Mutation Strain Type
Attribution
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Serpine1<tm1Mlg> | MGI:1857287 | Serpine1 | MGI:97608 | 5 |
Phenotypic Description
Shortened life span.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 465 | Congenital plasminogen activator inhibitor type 1 deficiency | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465 |
Publications
Displaying 81 - 90 of 229 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 21042583 | Stein S | ApoE-/- PGC-1?-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. | PLoS One (2 010) 5:e13539 |
| 9486990 | Xiao Q | Fibrinogen deficiency is compatible with the development of atherosclerosis in mice. | J Clin Invest (1 998) 101:1184-94 |
| 18469330 | Bajt ML | Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose. | Toxicol Sci (2 008) 104:419-27 |
| 21734232 | Courey AJ | The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice. | Blood (2 011) 118:2313-21 |
| 17652357 | Harslund J | Gender-dependent physiological implications of combined PAI-1 and TIMP-1 gene deficiency characterized in a mouse model. | Am J Physiol Regul Integr Comp Physiol (2 007) 293:R1630-9 |
| 15716324 | Koh TJ | Mice deficient in plasminogen activator inhibitor-1 have improved skeletal muscle regeneration. | Am J Physiol Cell Physiol (2 005) 289:C217-23 |
| 16528256 | Ma J | Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury. | Kidney Int (2 006) 69:1064-72 |
| 23940734 | Omouendze PL | Hypoxia-ischemia or excitotoxin-induced tissue plasminogen activator- dependent gelatinase activation in mice neonate brain microvessels. | PLoS One (2 013) 8:e71263 |
| 15944322 | Sejima T | Protection of plasminogen activator inhibitor-1-deficient mice from nasal allergy. | J Immunol (2 005) 174:8135-43 |
| 18197246 | Bhasin JM | Sex specific gene regulation and expression QTLs in mouse macrophages from a strain intercross. | PLoS One (2 008) 3:e1435 |
Pages
Orphanet Categories
Rare hematologic disease
EMMA ID
EM:02066
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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