Stock
FESA Number
2899
Strain Name
129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]
Mutation Strain Type
Attribution
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Serpine1<tm1Mlg> | MGI:1857287 | Serpine1 | MGI:97608 | 5 |
Phenotypic Description
Shortened life span.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 465 | Congenital plasminogen activator inhibitor type 1 deficiency | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465 |
Publications
Displaying 71 - 80 of 229 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 23254194 | Kenny S | Gastric expression of plasminogen activator inhibitor (PAI)-1 is associated with hyperphagia and obesity in mice. | Endocrinology (2 013) 154:718-26 |
| 18753414 | Maillard CM | Reduction of brain metastases in plasminogen activator inhibitor-1-deficient mice with transgenic ocular tumors. | Carcinogenesis (2 008) 29:2236-42 |
| 12074598 | Oh CK | PAI-1 promotes extracellular matrix deposition in the airways of a murine asthma model. | Biochem Biophys Res Commun (2 002) 294:1155-60 |
| 17067365 | Scroyen I | No functional role of plasminogen activator inhibitor-1 in murine adipogenesis or adipocyte differentiation. | J Thromb Haemost (2 007) 5:139-45 |
| 21622848 | Zmijewski JW | Inhibition of neutrophil apoptosis by PAI-1. | Am J Physiol Lung Cell Mol Physiol (2 011) 301:L247-54 |
| 9861024 | Bergeron N | Lamellar lipoproteins uniquely contribute to hyperlipidemia in mice doubly deficient in apolipoprotein E and hepatic lipase. | Proc Natl Acad Sci U S A (1 998) 95:15647-52 |
| 10441168 | George J | The involvement of beta2-glycoprotein I (beta2-GPI) in human and murine atherosclerosis. | J Autoimmun (1 999) 13:57-60 |
| 15781753 | Johnson J | Plaque rupture after short periods of fat feeding in the apolipoprotein E-knockout mouse: model characterization and effects of pravastatin treatment. | Circulation (2 005) 111:1422-30 |
| 16816382 | Liu H | Reduced acute vascular injury and atherosclerosis in hyperlipidemic mice transgenic for lysozyme. | Am J Pathol (2 006) 169:303-13 |
| 14688198 | Poch E | Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice. | FASEB J (2 004) 18:418-20 |
Pages
Orphanet Categories
Rare hematologic disease
EMMA ID
EM:02066
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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