Stock
FESA Number
2899
Strain Name
129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]
Mutation Strain Type
Attribution
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Serpine1<tm1Mlg> | MGI:1857287 | Serpine1 | MGI:97608 | 5 |
Phenotypic Description
Shortened life span.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 465 | Congenital plasminogen activator inhibitor type 1 deficiency | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465 |
Publications
Displaying 61 - 70 of 229 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 17215360 | Amirbekian V | Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI. | Proc Natl Acad Sci U S A (2 007) 104:961-6 |
| 7829881 | Feingold KR | Apolipoprotein E deficiency leads to cutaneous foam cell formation in mice. | J Invest Dermatol (1 995) 104:246-50 |
| 11433351 | Jiang XC | Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. | Nat Med (2 001) 7:847-52 |
| 10487844 | Licastro F | A role for apoE in regulating the levels of alpha-1-antichymotrypsin in the aging mouse brain and in Alzheimer's disease. | Am J Pathol (1 999) 155:869-75 |
| 7937814 | Plump AS | Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. | Proc Natl Acad Sci U S A (1 994) 91:9607-11 |
| 7667279 | Smith JD | Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. | Proc Natl Acad Sci U S A (1 995) 92:8264-8 |
| 12006391 | Williams H | Characteristics of intact and ruptured atherosclerotic plaques in brachiocephalic arteries of apolipoprotein E knockout mice. | Arterioscler Thromb Vasc Biol (2 002) 22:788-92 |
| 15286708 | Bajou K | Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth. | Oncogene (2 004) 23:6986-90 |
| 16735799 | Collins SJ | Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice. | Nephron Exp Nephrol (2 006) 104:e23-34 |
| 11059781 | Gutierrez LS | Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1. | Cancer Res (2 000) 60:5839-47 |
Pages
Orphanet Categories
Rare hematologic disease
EMMA ID
EM:02066
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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