Stock 129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]
FESA Number
2899
Strain Name
129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]
Mutation Strain Type
Attribution
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Serpine1<tm1Mlg> | MGI:1857287 | Serpine1 | MGI:97608 | 5 |
Phenotypic Description
Shortened life span.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 465 | Congenital plasminogen activator inhibitor type 1 deficiency | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465 |
Publications
Displaying 31 - 40 of 229 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 1712312 | Agarwal N | Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2). | Exp Eye Res (1 991) 52:549-61 |
| 9555870 | de Villiers WJ | Macrophage phenotype in mice deficient in both macrophage-colony-stimulating factor (op) and apolipoprotein E. | Arterioscler Thromb Vasc Biol (1 998) 18:631-40 |
| 14614151 | Idel S | A20, a regulator of NFkappaB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains. | Proc Natl Acad Sci U S A (2 003) 100:14235-40 |
| 12569158 | Lesnik P | Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis. | J Clin Invest (2 003) 111:333-40 |
| 1423598 | Plump AS | Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. | Cell (1 992) 71:343-53 |
| 11988491 | Silence J | Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue inhibitor of metalloproteinase-1 (TIMP-1) gene. | Circ Res (2 002) 90:897-903 |
| 8962133 | Weng W | Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. | Proc Natl Acad Sci U S A (1 996) 93:14788-94 |
| 18835034 | Bajou K | Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis. | Cancer Cell (2 008) 14:324-34 |
| 22293605 | Cho E | Neuroprotection by urokinase plasminogen activator in the hippocampus. | Neurobiol Dis (2 012) 46:215-24 |
| 20823384 | Ghosh AK | Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: involvement of constitutive transforming growth factor-beta signaling and endothelial-to-mesenchymal transition. | Circulation (2 010) 122:1200-9 |
Pages
Orphanet Categories
Rare hematologic disease
EMMA ID
EM:02066
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
Contact/Order
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