Stock

FESA Number

2899

Strain Name

129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Serpine1<tm1Mlg> MGI:1857287 Serpine1 MGI:97608 5

Phenotypic Description

Shortened life span.

Orphanet Disorders

OrphaNet ID Name Url
465 Congenital plasminogen activator inhibitor type 1 deficiency http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465

Publications

Displaying 221 - 229 of 229 Stock Publications
Pubmed ID Authors Title Journal
9358763 Walker LC Cerebral lipid deposition in aged apolipoprotein-E-deficient mice. Am J Pathol (1 997) 151:1371-7
12853975 Almholt K Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice. Oncogene (2 003) 22:4389-97
8254028 Carmeliet P Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. J Clin Invest (1 993) 92:2746-55
24778222 Eren M PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc Natl Acad Sci U S A (2 014) 111:7090-5
21423135 Kanuri G Fructose-induced steatosis in mice: role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells. Lab Invest (2 011) 91:885-95
17723219 Lim JH Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity (2 007) 27:349-60
15297377 Moriwaki H Overexpression of urokinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in mice. Circ Res (2 004) 95:637-44
18800031 Roelofs JJ Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis. Kidney Int (2 009) 75:52-9
17561000 Wang H PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA. FEBS Lett (2 007) 581:3098-104

Pages

Orphanet Categories

Rare hematologic disease

EMMA ID

EM:02066

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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