Stock
FESA Number
2899
Strain Name
129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]
Mutation Strain Type
Attribution
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Serpine1<tm1Mlg> | MGI:1857287 | Serpine1 | MGI:97608 | 5 |
Phenotypic Description
Shortened life span.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 465 | Congenital plasminogen activator inhibitor type 1 deficiency | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465 |
Publications
Displaying 221 - 229 of 229 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 9358763 | Walker LC | Cerebral lipid deposition in aged apolipoprotein-E-deficient mice. | Am J Pathol (1 997) 151:1371-7 |
| 12853975 | Almholt K | Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice. | Oncogene (2 003) 22:4389-97 |
| 8254028 | Carmeliet P | Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization. | J Clin Invest (1 993) 92:2746-55 |
| 24778222 | Eren M | PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. | Proc Natl Acad Sci U S A (2 014) 111:7090-5 |
| 21423135 | Kanuri G | Fructose-induced steatosis in mice: role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells. | Lab Invest (2 011) 91:885-95 |
| 17723219 | Lim JH | Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. | Immunity (2 007) 27:349-60 |
| 15297377 | Moriwaki H | Overexpression of urokinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in mice. | Circ Res (2 004) 95:637-44 |
| 18800031 | Roelofs JJ | Plasminogen activator inhibitor-1 regulates neutrophil influx during acute pyelonephritis. | Kidney Int (2 009) 75:52-9 |
| 17561000 | Wang H | PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA. | FEBS Lett (2 007) 581:3098-104 |
Pages
Orphanet Categories
Rare hematologic disease
EMMA ID
EM:02066
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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