Stock
FESA Number
2899
Strain Name
129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]
Mutation Strain Type
Attribution
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Serpine1<tm1Mlg> | MGI:1857287 | Serpine1 | MGI:97608 | 5 |
Phenotypic Description
Shortened life span.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 465 | Congenital plasminogen activator inhibitor type 1 deficiency | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465 |
Publications
Displaying 21 - 30 of 229 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 15694415 | Shimshi M | Bisphosphonates induce inflammation and rupture of atherosclerotic plaques in apolipoprotein-E null mice. | Biochem Biophys Res Commun (2 005) 328:790-3 |
| 16325305 | Wang ZJ | Alteration of vascular urotensin II receptor in mice with apolipoprotein E gene knockout. | Peptides (2 006) 27:858-63 |
| 16148154 | Arndt PG | Regulation of lipopolysaccharide-induced lung inflammation by plasminogen activator Inhibitor-1 through a JNK-mediated pathway. | J Immunol (2 005) 175:4049-59 |
| 11696429 | Chan JC | Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice. | Am J Pathol (2 001) 159:1681-8 |
| 15674349 | Fen Li C | Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor). | Oncogene (2 005) 24:1615-24 |
| 11157667 | Kawasaki T | Mouse carotid artery ligation induces platelet-leukocyte-dependent luminal fibrin, required for neointima development. | Circ Res (2 001) 88:159-66 |
| 21724997 | Luo D | Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. | J Immunol (2 011) 187:1866-76 |
| 15780082 | Nicholas SB | Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy. | Kidney Int (2 005) 67:1297-307 |
| 12818888 | Savov JD | Fibrinolysis in LPS-induced chronic airway disease. | Am J Physiol Lung Cell Mol Physiol (2 003) 285:L940-8 |
| 11792849 | Yamamoto K | Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals. | Proc Natl Acad Sci U S A (2 002) 99:890-5 |
Pages
Orphanet Categories
Rare hematologic disease
EMMA ID
EM:02066
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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