Stock

FESA Number

2899

Strain Name

129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Serpine1<tm1Mlg> MGI:1857287 Serpine1 MGI:97608 5

Phenotypic Description

Shortened life span.

Orphanet Disorders

OrphaNet ID Name Url
465 Congenital plasminogen activator inhibitor type 1 deficiency http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465

Publications

Displaying 21 - 30 of 229 Stock Publications
Pubmed ID Authors Title Journal
15694415 Shimshi M Bisphosphonates induce inflammation and rupture of atherosclerotic plaques in apolipoprotein-E null mice. Biochem Biophys Res Commun (2 005) 328:790-3
16325305 Wang ZJ Alteration of vascular urotensin II receptor in mice with apolipoprotein E gene knockout. Peptides (2 006) 27:858-63
16148154 Arndt PG Regulation of lipopolysaccharide-induced lung inflammation by plasminogen activator Inhibitor-1 through a JNK-mediated pathway. J Immunol (2 005) 175:4049-59
11696429 Chan JC Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice. Am J Pathol (2 001) 159:1681-8
15674349 Fen Li C Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor). Oncogene (2 005) 24:1615-24
11157667 Kawasaki T Mouse carotid artery ligation induces platelet-leukocyte-dependent luminal fibrin, required for neointima development. Circ Res (2 001) 88:159-66
21724997 Luo D Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica. J Immunol (2 011) 187:1866-76
15780082 Nicholas SB Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy. Kidney Int (2 005) 67:1297-307
12818888 Savov JD Fibrinolysis in LPS-induced chronic airway disease. Am J Physiol Lung Cell Mol Physiol (2 003) 285:L940-8
11792849 Yamamoto K Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals. Proc Natl Acad Sci U S A (2 002) 99:890-5

Pages

Orphanet Categories

Rare hematologic disease

EMMA ID

EM:02066

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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