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Stock 129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

FESA Number

2899

Strain Name

129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Serpine1<tm1Mlg> MGI:1857287 Serpine1 MGI:97608 5

Phenotypic Description

Shortened life span.

Orphanet Disorders

OrphaNet ID Name Url
465 Congenital plasminogen activator inhibitor type 1 deficiency http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=465

Publications

Displaying 101 - 110 of 229 Stock Publications
Pubmed ID Authors Title Journal
14747283 Ma LJ Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes (2 004) 53:336-46
22262246 Osterholzer JJ PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury. J Pathol (2 012) 228:170-80
18359942 Shah C Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem (2 008) 283:13538-48
19941948 Bonomini F Apolipoprotein E and its role in aging and survival. Exp Gerontol (2 010) 45:149-57
9169506 Gupta S IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest (1 997) 99:2752-61
16221765 Johnson JL Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries. Proc Natl Acad Sci U S A (2 005) 102:15575-80
10720491 Maor I Oxidized monocyte-derived macrophages in aortic atherosclerotic lesion from apolipoprotein E-deficient mice and from human carotid artery contain lipid peroxides and oxysterols. Biochem Biophys Res Commun (2 000) 269:775-80
15567863 Ricci R Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science (2 004) 306:1558-61
14976060 Tan MH Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis. Blood (2 004) 104:11-8
21889487 Xu S Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet. Arch Biochem Biophys (2 011) 515:72-9

Pages

Orphanet Categories

Rare hematologic disease

EMMA ID

EM:02066

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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