Stock 129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

FESA Number


Strain Name

129(B6)-Serpine1<tm1Mlg> Apoe<tm1Bres>/CljH[cc]

Mutation Strain Type


Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Serpine1<tm1Mlg> MGI:1857287 Serpine1 MGI:97608 5

Phenotypic Description

Shortened life span.

Orphanet Disorders

OrphaNet ID Name Url
465 Congenital plasminogen activator inhibitor type 1 deficiency


Displaying 11 - 20 of 229 Stock Publications
Pubmed ID Authors Title Journal
10891445 Kawasaki T Vascular release of plasminogen activator inhibitor-1 impairs fibrinolysis during acute arterial thrombosis in mice. Blood (2 000) 96:153-60
19604604 Liu RM Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease. Neurobiol Aging (2 011) 32:1079-89
10318667 Nagai N Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice. Circulation (1 999) 99:2440-4
16460449 Rossignol P Plasminogen activation: a mediator of vascular smooth muscle cell apoptosis in atherosclerotic plaques. J Thromb Haemost (2 006) 4:664-70
20009036 Xu Z Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood (2 010) 115:2038-47
15126104 Afek A Evidence for the involvement of T cell costimulation through the B-7/CD28 pathway in atherosclerotic plaques from apolipoprotein E knockout mice. Exp Mol Pathol (2 004) 76:219-23
12600880 Deng GG Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm. Circ Res (2 003) 92:510-7
22366371 Huang Y Aberrant expression of Fc?RIIIA (CD16) contributes to the development of atherosclerosis. Gene (2 012) 498:91-5
15466367 Lee SJ Chylomicron remnant uptake in the livers of mice expressing human apolipoproteins E3, E2 (Arg158--&gt;Cys), and E3-Leiden. J Lipid Res (2 004) 45:2199-210
10195942 Plump AS Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression. Arterioscler Thromb Vasc Biol (1 999) 19:1105-10


Orphanet Categories

Rare hematologic disease



Genetic Status


Background Strain Name


Background Strain MGI ID



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