Stock

FESA Number

2900

Strain Name

129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Plg<tm1Jld> MGI:1857291 Plg MGI:97620 17

Phenotypic Description

Rectal prolapse. Shortened life span in homozygotes.

Orphanet Disorders

Publications

Displaying 81 - 90 of 171 Stock Publications
Pubmed ID Authors Title Journal
10720491 Maor I Oxidized monocyte-derived macrophages in aortic atherosclerotic lesion from apolipoprotein E-deficient mice and from human carotid artery contain lipid peroxides and oxysterols. Biochem Biophys Res Commun (2 000) 269:775-80
15567863 Ricci R Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science (2 004) 306:1558-61
14976060 Tan MH Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis. Blood (2 004) 104:11-8
21889487 Xu S Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet. Arch Biochem Biophys (2 011) 515:72-9
10559390 Chen ZL Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes. J Neurosci (1 999) 19:9813-20
10642175 List K Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice. Biochemistry (2 000) 39:508-15
11733368 Pohl JF Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury. Am J Pathol (2 001) 159:2179-86
12070304 Yepes M Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent. J Clin Invest (2 002) 109:1571-8
8816744 Bourassa PA Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A (1 996) 93:10022-7
14525797 Hayek T Tissue angiotensin-converting-enzyme (ACE) deficiency leads to a reduction in oxidative stress and in atherosclerosis: studies in ACE-knockout mice type 2. Arterioscler Thromb Vasc Biol (2 003) 23:2090-6

Pages

Orphanet Categories

Rare systemic or rheumatologic disease
Rare eye disease

EMMA ID

EM:02065

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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