Stock

FESA Number

2900

Strain Name

129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Plg<tm1Jld> MGI:1857291 Plg MGI:97620 17

Phenotypic Description

Rectal prolapse. Shortened life span in homozygotes.

Orphanet Disorders

Publications

Displaying 71 - 80 of 171 Stock Publications
Pubmed ID Authors Title Journal
25474352 Ramsey SA Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway. PLoS Genet (2 014) 10:e1004828
10195908 Tamminen M Ultrastructure of early lipid accumulation in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (1 999) 19:847-53
9294211 Xiao Q Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis. Proc Natl Acad Sci U S A (1 997) 94:10335-40
23943648 Chen PK Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis. FASEB J (2 013) 27:4520-31
18957535 Kremen M Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice. Proc Natl Acad Sci U S A (2 008) 105:17109-14
15630096 Pawlak R Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors. Proc Natl Acad Sci U S A (2 005) 102:443-8
9294211 Xiao Q Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis. Proc Natl Acad Sci U S A (1 997) 94:10335-40
19941948 Bonomini F Apolipoprotein E and its role in aging and survival. Exp Gerontol (2 010) 45:149-57
9169506 Gupta S IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest (1 997) 99:2752-61
16221765 Johnson JL Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteries. Proc Natl Acad Sci U S A (2 005) 102:15575-80

Pages

Orphanet Categories

Rare systemic or rheumatologic disease
Rare eye disease

EMMA ID

EM:02065

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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