Stock
FESA Number
2900
Strain Name
129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]
Mutation Strain Type
Attribution
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Plg<tm1Jld> | MGI:1857291 | Plg | MGI:97620 | 17 |
Phenotypic Description
Rectal prolapse. Shortened life span in homozygotes.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 722 | Hypoplasminogenemia | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=722 |
| 97 231 | Ligneous conjunctivitis | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=97231 |
Publications
Displaying 51 - 60 of 171 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 12006391 | Williams H | Characteristics of intact and ruptured atherosclerotic plaques in brachiocephalic arteries of apolipoprotein E knockout mice. | Arterioscler Thromb Vasc Biol (2 002) 22:788-92 |
| 9671388 | Bugge TH | Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice. | Oncogene (1 998) 16:3097-104 |
| 21931322 | Ishihara M | Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b(+)/F4/80(+) myeloid cell recruitment. | Leukemia (2 012) 26:332-9 |
| 17664291 | Paul J | Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. | J Exp Med (2 007) 204:1999-2008 |
| 9275201 | Tsirka SE | Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin. | Proc Natl Acad Sci U S A (1 997) 94:9779-81 |
| 9861024 | Bergeron N | Lamellar lipoproteins uniquely contribute to hyperlipidemia in mice doubly deficient in apolipoprotein E and hepatic lipase. | Proc Natl Acad Sci U S A (1 998) 95:15647-52 |
| 10441168 | George J | The involvement of beta2-glycoprotein I (beta2-GPI) in human and murine atherosclerosis. | J Autoimmun (1 999) 13:57-60 |
| 15781753 | Johnson J | Plaque rupture after short periods of fat feeding in the apolipoprotein E-knockout mouse: model characterization and effects of pravastatin treatment. | Circulation (2 005) 111:1422-30 |
| 16816382 | Liu H | Reduced acute vascular injury and atherosclerosis in hyperlipidemic mice transgenic for lysozyme. | Am J Pathol (2 006) 169:303-13 |
| 14688198 | Poch E | Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice. | FASEB J (2 004) 18:418-20 |
Pages
Orphanet Categories
Rare systemic or rheumatologic disease
Rare eye disease
EMMA ID
EM:02065
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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