Stock 129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]
FESA Number
2900
Strain Name
129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]
Mutation Strain Type
Attribution
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Plg<tm1Jld> | MGI:1857291 | Plg | MGI:97620 | 17 |
Phenotypic Description
Rectal prolapse. Shortened life span in homozygotes.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 722 | Hypoplasminogenemia | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=722 |
| 97 231 | Ligneous conjunctivitis | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=97231 |
Publications
Displaying 161 - 170 of 171 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 19286661 | Shanmukhappa K | Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair. | J Biol Chem (2 009) 284:12917-23 |
| 10393696 | Dansky HM | Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endothelium. | J Clin Invest (1 999) 104:31-9 |
| 11551841 | Hirano T | Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E. | Am J Physiol Endocrinol Metab (2 001) 281:E665-9 |
| 15625075 | Lassila M | Imatinib attenuates diabetic nephropathy in apolipoprotein E-knockout mice. | J Am Soc Nephrol (2 005) 16:363-73 |
| 7511933 | Palinski W | ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. | Arterioscler Thromb (1 994) 14:605-16 |
| 19359600 | She ZG | Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice. | Circ Res (2 009) 104:1160-8 |
| 9358763 | Walker LC | Cerebral lipid deposition in aged apolipoprotein-E-deficient mice. | Am J Pathol (1 997) 151:1371-7 |
| 15161662 | Bolon I | Plasminogen mediates the pathological effects of urokinase-type plasminogen activator overexpression. | Am J Pathol (2 004) 164:2299-304 |
| 20440070 | Echeverry R | Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus. | J Clin Invest (2 010) 120:2194-205 |
| 20110420 | Ohki M | Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. | Blood (2 010) 115:4302-12 |
Pages
Orphanet Categories
Rare systemic or rheumatologic disease
Rare eye disease
EMMA ID
EM:02065
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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