Stock

FESA Number

2900

Strain Name

129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Plg<tm1Jld> MGI:1857291 Plg MGI:97620 17

Phenotypic Description

Rectal prolapse. Shortened life span in homozygotes.

Orphanet Disorders

Publications

Displaying 161 - 170 of 171 Stock Publications
Pubmed ID Authors Title Journal
19286661 Shanmukhappa K Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair. J Biol Chem (2 009) 284:12917-23
10393696 Dansky HM Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endothelium. J Clin Invest (1 999) 104:31-9
11551841 Hirano T Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E. Am J Physiol Endocrinol Metab (2 001) 281:E665-9
15625075 Lassila M Imatinib attenuates diabetic nephropathy in apolipoprotein E-knockout mice. J Am Soc Nephrol (2 005) 16:363-73
7511933 Palinski W ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arterioscler Thromb (1 994) 14:605-16
19359600 She ZG Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice. Circ Res (2 009) 104:1160-8
9358763 Walker LC Cerebral lipid deposition in aged apolipoprotein-E-deficient mice. Am J Pathol (1 997) 151:1371-7
15161662 Bolon I Plasminogen mediates the pathological effects of urokinase-type plasminogen activator overexpression. Am J Pathol (2 004) 164:2299-304
20440070 Echeverry R Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus. J Clin Invest (2 010) 120:2194-205
20110420 Ohki M Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Blood (2 010) 115:4302-12

Pages

Orphanet Categories

Rare systemic or rheumatologic disease
Rare eye disease

EMMA ID

EM:02065

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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