Stock

FESA Number

2900

Strain Name

129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Plg<tm1Jld> MGI:1857291 Plg MGI:97620 17

Phenotypic Description

Rectal prolapse. Shortened life span in homozygotes.

Orphanet Disorders

Publications

Displaying 131 - 140 of 171 Stock Publications
Pubmed ID Authors Title Journal
17722076 Roszell NJ Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice. Am J Hematol (2 007) 82:1044-8
9453565 Chapman S Specific neurochemical derangements of brain projecting neurons in apolipoprotein E-deficient mice. J Neurochem (1 998) 70:708-14
16043658 Heller EA Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation (2 005) 112:578-86
9245700 Keidar S The angiotensin-II receptor antagonist, losartan, inhibits LDL lipid peroxidation and atherosclerosis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun (1 997) 236:622-5
8274468 Nakashima Y ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb (1 994) 14:133-40
22952653 Schurgers LJ Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype. PLoS One (2 012) 7:e43229
10336088 Veinbergs I Synaptic alterations in apolipoprotein E knockout mice. Neuroscience (1 999) 91:401-3
18689793 Zhang QJ Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res (2 008) 80:191-9
9473227 Drew AF Ligneous conjunctivitis in plasminogen-deficient mice. Blood (1 998) 91:1616-24
16763560 Lund LR Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. EMBO J (2 006) 25:2686-97

Pages

Orphanet Categories

Rare systemic or rheumatologic disease
Rare eye disease

EMMA ID

EM:02065

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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