Stock

FESA Number

2900

Strain Name

129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]

Mutation Strain Type

Attribution

Gene/Allele Information

Allele Name Allele MGI ID Gene Name Gene MGI ID Chromosome
Apoe<tm1Bres> MGI:2137814 Apoe MGI:88057 7
Plg<tm1Jld> MGI:1857291 Plg MGI:97620 17

Phenotypic Description

Rectal prolapse. Shortened life span in homozygotes.

Orphanet Disorders

Publications

Displaying 121 - 130 of 171 Stock Publications
Pubmed ID Authors Title Journal
17717150 Zhang X Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-kappaB pathway activation. Am J Pathol (2 007) 171:1281-90
9398846 Carmeliet P Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation. Nat Genet (1 997) 17:439-44
16682613 Heller EA Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation (2 006) 113:2301-12
10532681 Keidar S Angiotensin II atherogenicity in apolipoprotein E deficient mice is associated with increased cellular cholesterol biosynthesis. Atherosclerosis (1 999) 146:249-57
11454984 Mulder M Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging. Lab Invest (2 001) 81:953-60
18467709 Schulte S Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis. Am J Pathol (2 008) 172:1500-8
11421580 Veinbergs I Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E. Exp Neurol (2 001) 170:15-26
12860569 Yuan Z Immunoglobulin treatment suppresses atherosclerosis in apolipoprotein E-deficient mice via the Fc portion. Am J Physiol Heart Circ Physiol (2 003) 285:H899-906
12431907 Currier AR Plasminogen directs the pleiotropic effects of uPA in liver injury and repair. Am J Physiol Gastrointest Liver Physiol (2 003) 284:G508-15
11003846 Lund LR Lactational competence and involution of the mouse mammary gland require plasminogen. Development (2 000) 127:4481-92

Pages

Orphanet Categories

Rare systemic or rheumatologic disease
Rare eye disease

EMMA ID

EM:02065

Genetic Status

GMO

Background Strain Name

129

Background Strain MGI ID

MGI:2160041

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