Stock 129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]
FESA Number
2900
Strain Name
129(B6)-Apoe<tm1Bres> Plg<tm1Jld>/CljH[cc]
Mutation Strain Type
Attribution
Gene/Allele Information
| Allele Name | Allele MGI ID | Gene Name | Gene MGI ID | Chromosome |
|---|---|---|---|---|
| Apoe<tm1Bres> | MGI:2137814 | Apoe | MGI:88057 | 7 |
| Plg<tm1Jld> | MGI:1857291 | Plg | MGI:97620 | 17 |
Phenotypic Description
Rectal prolapse. Shortened life span in homozygotes.
Orphanet Disorders
| OrphaNet ID | Name | Url |
|---|---|---|
| 722 | Hypoplasminogenemia | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=722 |
| 97 231 | Ligneous conjunctivitis | http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=97231 |
Publications
Displaying 121 - 130 of 171 Stock Publications
| Pubmed ID | Authors | Title | Journal |
|---|---|---|---|
| 17717150 | Zhang X | Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-kappaB pathway activation. | Am J Pathol (2 007) 171:1281-90 |
| 9398846 | Carmeliet P | Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation. | Nat Genet (1 997) 17:439-44 |
| 16682613 | Heller EA | Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. | Circulation (2 006) 113:2301-12 |
| 10532681 | Keidar S | Angiotensin II atherogenicity in apolipoprotein E deficient mice is associated with increased cellular cholesterol biosynthesis. | Atherosclerosis (1 999) 146:249-57 |
| 11454984 | Mulder M | Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging. | Lab Invest (2 001) 81:953-60 |
| 18467709 | Schulte S | Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis. | Am J Pathol (2 008) 172:1500-8 |
| 11421580 | Veinbergs I | Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E. | Exp Neurol (2 001) 170:15-26 |
| 12860569 | Yuan Z | Immunoglobulin treatment suppresses atherosclerosis in apolipoprotein E-deficient mice via the Fc portion. | Am J Physiol Heart Circ Physiol (2 003) 285:H899-906 |
| 12431907 | Currier AR | Plasminogen directs the pleiotropic effects of uPA in liver injury and repair. | Am J Physiol Gastrointest Liver Physiol (2 003) 284:G508-15 |
| 11003846 | Lund LR | Lactational competence and involution of the mouse mammary gland require plasminogen. | Development (2 000) 127:4481-92 |
Pages
Orphanet Categories
Rare systemic or rheumatologic disease
Rare eye disease
EMMA ID
EM:02065
Genetic Status
GMO
Background Strain Name
129
Background Strain MGI ID
MGI:2160041
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